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The relationship between metabolic syndrome, its components, and the whole-body atherosclerotic disease burden as measured by computed tomography angiography

      Abstract

      Objective

      Quantify the whole-body atherosclerotic disease in asymptomatic subjects with and without metabolic syndrome (MetS) and to assess the contribution of the syndrome and its components to the atherosclerotic burden.

      Methods

      Sixty-five subjects with and 51 without ATPIII-defined MetS underwent a 64-slice computed tomography angiography (CTA). Plaques causing >0% stenosis in coronary or extra-coronary arteries were classified as positive.

      Results

      The prevalence of plaques in coronary, carotid and peripheral arteries as well as their severity did not differ between groups. Conversely, it was seen an almost 3-fold increased likelihood (OR = 2.70; 95% CI 1.30–5.57; P < 0.001) of atherosclerosis in any district across categories of MetS components (0–1 vs. 2–3 vs. 4–5). Hypertriglyceridemia (P < 0.05) and high blood glucose (P < 0.05) were independent predictors of the atherosclerotic burden.

      Conclusions

      Atherosclerotic burden as revealed by 64-TCA appears to be more strongly associated with the number of MetS-related factors than to the clinical diagnosis of MetS itself.

      Keywords

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      References

        • Gami A.S.
        • Witt B.J.
        • Howard D.E.
        • et al.
        Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies.
        J Am Coll Cardiol. 2007; 49: 403-414
        • Wong N.D.
        • Sciammarella M.G.
        • Polk D.
        • et al.
        The metabolic syndrome, diabetes, and sub-clinical atherosclerosis assessed by coronary calcium.
        J Am Coll Cardiol. 2003; 41: 1547-1553
        • Kullo I.J.
        • Cassidy A.E.
        • Peyser P.A.
        • Turner S.T.
        • Sheedy P.F.I.I.
        • Bielak L.F.
        Association between metabolic syndrome and subclinical coronary atherosclerosis in asymptomatic adults.
        Am J Cardiol. 2004; 94: 1554-1558
        • Ellison R.C.
        • Zhang Y.
        • Wagenknecht L.E.
        • et al.
        Relation of the metabolic syndrome to calcified atherosclerotic plaque in the coronary arteries and aorta.
        Am J Cardiol. 2005; 95: 1180-1186
        • Campbell C.Y.
        • Nasir K.
        • Sarwar A.
        • et al.
        Combined effect of high low-density lipoprotein cholesterol and metabolic syndrome on subclinical coronary atherosclerosis in white men without clinical evidence of myocardial ischemia.
        Am J Cardiol. 2007; 100: 840-843
        • Chen K.
        • Lindsey J.B.
        • Khera A.
        • et al.
        Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: observations from the Dallas Heart Study.
        Diab Vasc Dis Res. 2008; 5: 96-101
        • Ergün E.
        • Koşar P.
        • Oztürk C.
        • Başbay E.
        • Koç F.
        • Koşar U.
        Prevalence and extent of coronary artery disease determined by 64-slice CTA in patients with zero coronary calcium score.
        Int J Cardiovasc Imaging. 2010; https://doi.org/10.1007/s10554-010-9681-5
        • Mellen P.B.
        • Cefalu W.T.
        • Herrington D.M.
        Diabetes, the metabolic syndrome, and angiographic progression of coronary arterial disease in postmenopausal women.
        Arterioscler Thromb Vasc Biol. 2006; 26: 189-193
        • Konstantinou D.M.
        • Chatzizisis Y.S.
        • Louridas G.E.
        • Giannoglou G.D.
        Metabolic syndrome and angiographic coronary artery disease prevalence in association with the Framingham risk score.
        Met Syndr Relat Disord. 2010; 8: 201-208
        • Sattar N.
        • McConnachie A.
        • Shaper A.G.
        • et al.
        Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies.
        Lancet. 2008; 371: 1927-1935
        • Butler J.
        • Mooyaart E.A.
        • Dannemann N.
        • et al.
        Relation of the metabolic syndrome to quantity of coronary atherosclerotic plaque.
        Am J Cardiol. 2008; 101: 1127-1130
        • Grundy S.M.
        • Cleeman J.I.
        • Daniels S.R.
        • et al.
        Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute scientific statement.
        Circulation. 2005; 112: 2735-2752
        • Napoli A.
        • Catalano C.
        • Francone M.
        • et al.
        Imaging coronary and extracoronary atherosclerosis: feasibility and impact of whole-body computed tomography angiography.
        Eur Radiol. 2009; 19: 1704-1714
        • Bayturan O.
        • Tuzcu E.M.
        • Lavoie A.
        • et al.
        The metabolic syndrome, its component risk factors, and progression of coronary atherosclerosis.
        Arch Intern Med. 2010; 170: 478-484
        • Janssen I.
        • Katzmarzyk P.T.
        • Ross R.
        Body mass index, waist circumference, and health risk. Evidence in support of current National Institute of Health Guidelines.
        Arch Intern Med. 2002; 162: 2074-2079