Abstract
Objective
Quantify the whole-body atherosclerotic disease in asymptomatic subjects with and
without metabolic syndrome (MetS) and to assess the contribution of the syndrome and
its components to the atherosclerotic burden.
Methods
Sixty-five subjects with and 51 without ATPIII-defined MetS underwent a 64-slice computed
tomography angiography (CTA). Plaques causing >0% stenosis in coronary or extra-coronary
arteries were classified as positive.
Results
The prevalence of plaques in coronary, carotid and peripheral arteries as well as
their severity did not differ between groups. Conversely, it was seen an almost 3-fold
increased likelihood (OR = 2.70; 95% CI 1.30–5.57; P < 0.001) of atherosclerosis in any district across categories of MetS components (0–1
vs. 2–3 vs. 4–5). Hypertriglyceridemia (P < 0.05) and high blood glucose (P < 0.05) were independent predictors of the atherosclerotic burden.
Conclusions
Atherosclerotic burden as revealed by 64-TCA appears to be more strongly associated
with the number of MetS-related factors than to the clinical diagnosis of MetS itself.
Keywords
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Article info
Publication history
Published online: February 09, 2011
Accepted:
December 25,
2010
Received in revised form:
December 13,
2010
Received:
October 3,
2010
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
