Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials

  • Author Footnotes
    d Both authors contributed equally to this work.
    Linggen Gao
    d Both authors contributed equally to this work.
    Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China
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  • Author Footnotes
    d Both authors contributed equally to this work.
    Qunxia Mao
    d Both authors contributed equally to this work.
    National Research Institute for Family Planning, Beijing 100081, China
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  • Jian Cao
    Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China
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  • Yutang Wang
    Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China
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  • Xianliang Zhou
    Corresponding author. Tel.: +86 10 8839 8056; fax: +86 10 8839 8358.
    Department of Cardiology, FuWai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China
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  • Li Fan
    Corresponding author. Tel.: +86 10 6693 9103; fax: +86 10 6693 9103.
    Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China
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  • Author Footnotes
    d Both authors contributed equally to this work.



      The purpose of this study was to quantify the effect of coenzyme Q10 on arterial endothelial function in patients with and without established cardiovascular disease.


      Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis.

      Methods and results

      The search included MEDLINE, Cochrane Library, Scopus, and EMBASE to identify studies up to 1 July 2011. Eligible studies were randomized controlled trials on the effects of coenzyme Q10 compared with placebo on endothelial function. Two reviewers extracted data on study characteristics, methods, and outcomes. Five eligible trials enrolled a total of 194 patients. Meta-analysis using random-effects model showed treatment with coenzyme Q10 significantly improvement in endothelial function assessed peripherally by flow-mediated dilatation (SMD 1.70, 95% CI: 1.00–2.4, p < 0.0001). However, the endothelial function assessed peripherally by nitrate-mediated arterial dilatation was not significantly improved by using fix-effects model (SMD −0.19, 95% CI: −1.75 to 1.38, p = 0.81).


      Coenzyme Q10 supplementation is associated with significant improvement in endothelial function. The current study supports a role for CoQ10 supplementation in patients with endothelial dysfunction.


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