Taking effective action against type 2 diabetes and obesity has remained an enormous
challenge. Latest estimates indicate that type 2 diabetes is globally affecting at
least 366 million people, and that around 500 million adults are obese [
1
,
International Diabetes Federation. http://www.idf.org/diabetesatlas/5e/the-global-burden; 2011.
2
]. Alarmingly, over 20% of US children aged 2–5 years are overweight or obese [
[3]
]. Better understanding of the causes of these diseases is essential for both prevention
and treatment [
US Institute of Medicine. http://www.iom.edu/Reports/2011/Early-Childhood-Obesity-Prevention-Policies.aspx; 2011.
[4]
].Keywords
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References
International Diabetes Federation. http://www.idf.org/diabetesatlas/5e/the-global-burden; 2011.
- National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants.Lancet. 2011; 377: 557-567
US Institute of Medicine. http://www.iom.edu/Reports/2011/Early-Childhood-Obesity-Prevention-Policies.aspx; 2011.
- Persistent organic pollutants and the burden of diabetes.Lancet. 2006; 368: 558-559
- Chemical toxins: a hypothesis to explain the global obesity epidemic.J Altern Complem Med. 2002; 8: 185-192
- Role of environmental chemicals in diabetes and obesity: a national toxicology program workshop report.Environ Health Perspect. 2012; (http://dx.doi.org/10.1289/ehp.1104597)
- Endocrine disruptors: from endocrine to metabolic disruption.Annu Rev Physiol. 2011; 73: 135-162
- Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes.Plos One. 2011; 6: e15977
- Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama.J Hypertens. 2010; 28: 2053-2060
- Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study.Diabetes Care. 2011; 34: 1778-1784
- Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case–control study.Environ Health Perspect. 2010; 118: 1235-1242
- Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus.Epidemiology. 2006; 17: 352-359
- Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers.Environ Health Perspect. 2009; 117: 1076-1082
- Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort.Diabetes Care. 2008; 31: 1574-1579
- Persistent organic pollutant exposure leads to insulin resistance syndrome.Environ Health Perspect. 2010; 118: 465-471
- Perfluorinated compounds, polychlorinated biphenyls, and organochlorine pesticide contamination in composite food samples from Dallas, Texas, USA.Environ Health Perspect. 2010; 118: 796-802
- Polychlorinated biphenyls (PCBs): routes of exposure and effects on human health.Rev Environ Health. 2006; 21: 1-23
- Hypothesis: a unifying mechanism for nutrition and chemicals as lifelong modulators of DNA hypomethylation.Environ Health Perspect. 2009; 117: 1799-1802
- Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice.Plos One. 2011; 6: e25170
- Global assessment of organic contaminants in farmed salmon.Science. 2004; 303: 226-229
- Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes.Am J Clin Nutr. 2011; 93: 143-150
- Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus.Am J Clin Nutr. 2009; 90: 613-620
- Association between type 2 diabetes and exposure to persistent organic pollutants.Diabetes Care. 2011; 34: 1972-1979
- Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis.Environ Health Perspect. 2008; 116: 761-768
State of the art report on mixture toxicity. European Commission; 2009.
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin (HxCDD) alter body weight by decreasing insulin-like growth factor I (IGF-I) signaling.Toxicol Sci. 2005; 85: 560-571
- Environmental causes of cancer: endocrine disruptors as carcinogens.Nat Rev Endocrinol. 2010; 6: 363-370
- Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.Mutat Res. 2009; 682: 94-109
Article info
Publication history
Published online: April 03, 2012
Accepted:
February 27,
2012
Received in revised form:
February 24,
2012
Received:
January 24,
2012
Footnotes
⋆Grants support: Our research is financially supported by the Research Council of Norway (J.R.), and the Institute of Health and the Environment of the University of Albany (D.O.C.).
Identification
Copyright
© 2012 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
