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Dietary treatment with rice containing resistant starch improves markers of endothelial function with reduction of postprandial blood glucose and oxidative stress in patients with prediabetes or newly diagnosed type 2 diabetes

  • Author Footnotes
    1 These two authors contributed equally to this work.
    Jung Hyun Kwak
    Footnotes
    1 These two authors contributed equally to this work.
    Affiliations
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea
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  • Author Footnotes
    1 These two authors contributed equally to this work.
    Jean Kyung Paik
    Footnotes
    1 These two authors contributed equally to this work.
    Affiliations
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea
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  • Hye In Kim
    Affiliations
    National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Republic of Korea
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  • Oh Yoen Kim
    Affiliations
    Department of Food Science and Nutrition, Dong-A University, Busan, Republic of Korea
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  • Dong Yeob Shin
    Affiliations
    Endocrinology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea
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  • Hye-Jin Kim
    Affiliations
    CJ Food R&D, CJ Corp., Seoul, Republic of Korea
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  • Jin Hee Lee
    Affiliations
    Department of Food Science and Biotechnology, CHA University, Gyeonggi-do, Republic of Korea
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  • Jong Ho Lee
    Correspondence
    Corresponding author. Department of Food & Nutrition, College of Human Ecology, Yonsei University, 134 Shinchon-dong, Sudaemun-Gu, Seoul 120-749, Republic of Korea. Tel.: +82 2 2123 3122; fax: +82 2 364 9605.
    Affiliations
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea

    National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Republic of Korea
    Search for articles by this author
  • Author Footnotes
    1 These two authors contributed equally to this work.

      Abstract

      Objective

      We aimed to evaluate whether 4-week of dietary treatment with rice containing resistant starch reduces blood glucose and oxidative stress as well as improves endothelial function.

      Methods

      Patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly diagnosed type 2 diabetes (n = 90) were randomly assigned to either a group ingesting rice containing 6.51 g resistant starch daily or a control rice group for 4-weeks. We assessed fasting and postprandial levels of glucose and insulin, oxidative stress markers and endothelial function using reactive hyperemia peripheral arterial tonometry (RH-PAT).

      Results

      The diet containing rice with resistant starch reduced fasting insulin and insulin resistance, postprandial glucose (P = 0.010) and insulin levels at 30 min, and glucose and insulin areas under the response curve after the standard meal. Rice with resistant starch also decreased urinary 8-epi-PGF and plasma malondialdehyde (MDA) and increased the RH-PAT index (P < 0.001) and total nitric oxide (NO). Postprandial changes in glucose at 60 and 120 min and areas under the glucose response curve, MDA, RH-PAT, and total NO of the test group differed significantly from those in the control even after adjusting for baseline values. Overall, changes in the RH-PAT index correlated positively with changes in total NO (r = 0.336, P = 0.003) and superoxide dismutase activity (r = 0.381, P = 0.001) and negatively with changes in MDA (r = −0.358, P = 0.002) and 8-epi-PGF.

      Conclusions

      In patients with IFG, IGT or newly diagnosed type 2 diabetes, 4-weeks of dietary treatment with rice containing resistant starch was associated with improved endothelial function with reduction of postprandial glucose and oxidative stress compared with control.

      Highlights

      • We assessed levels of glucose and insulin, oxidative stress markers and RH-PAT.
      • Dietary treatment was associated with improved endothelial function.
      • Resistant starch was related to reduce of postprandial glucose and oxidative stress.

      Keywords

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