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ABO gene variants and increased risk of atherosclerosis

      Variations at the ABO locus have been associated to circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, soluble E-selectin and to other markers known to participate in inflammatory processes by promoting adhesion of leukocytes to vascular wall endothelium. Soluble levels of these molecules have been shown to be associated to adverse cardiovascular events because of direct consequences on plaque stability and thrombogenesis [
      • Paterson A.D.
      • Lopes-Virella M.F.
      • Waggott D.
      • et al.
      Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.
      ].

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