Abstract
Objective
The benefits of fish oil fatty acids eicosapentaenoic (EPA) and docosahexaenoic acids
(DHA) on plasma lipid profiles have been inconsistent but may partially depend on
individual Apolipoprotein E (APOE) genotypes. We aimed to determine whether APOE genotype modifies the association of lipid profile characteristics with plasma EPA
and DHA levels.
Methods
APOE genotype was determined in this cross-sectional analysis of 2340 Multi-Ethnic Study
of Atherosclerosis (MESA) participants. Relative plasma phospholipid EPA and DHA levels,
plasma lipids, and lipoprotein subclass particle sizes and concentrations were measured.
Results
Significant gene-EPA interactions were found with HDL-C, and particle concentrations
of large and total HDL (pinteraction = 0.0002, 0.006, and 0.007, respectively). The above lipid targets were positively
associated with EPA in the E2 groups, whereas negative trends were observed among
the E4 participants. Gene-DHA interactions were noted for small LDL particle concentrations
alone (pinteraction = 0.01), where a positive trend was found among E4 but not E2 or E3 participants.
Conclusions
These results indicate a significant contribution of the APOE genotype to the EPA-lipid profile relationship; however, the results do not explain
the differences in previous findings regarding LDL-C, triglycerides or total cholesterol.
Future investigators examining the effects of EPA on HDL-C or lipoprotein characteristics
may consider including APOE genotype in their analyses.
Highlights
- A cross-sectional study among 2340 free-living and apparently healthy subjects.
- APOE genotype, plasma phospholipid EPA, DHA, and plasma lipid profiles were measured.
- APOE-EPA interactions were found with HDL-C, and large and total HDL particles.
- An APOE-DHA interaction was found for small LDL particle concentrations.
Keywords
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Article info
Publication history
Published online: March 06, 2013
Accepted:
February 4,
2013
Received in revised form:
December 17,
2012
Received:
September 4,
2012
Identification
Copyright
© 2013 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
