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Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography – The growing versatility of NLR

      Arbel et al. are the first group to demonstrate the correlation between Neutrophil/lymphocyte ratio (NLR) and severity of coronary artery disease (CAD) [
      • Arbel Y.
      • Finkelstein A.
      • Halkin A.
      • et al.
      Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography.
      ]. NLR is a recent area of increased research interest with 166 citations in 2012, compared to 87 in 2011 indexed in the NIH library [

      Pubmed Health. National Library of medicine (US) [Online] Available at: http://www.ncbi.nlm.nih.gov/pubmed?term=neutrophil%20lymphocyte%20ratio [accessed 10.01.12].

      ]. This research has been into a wide range of topics, including the use of NLR in cancer prognostication, cancer chemotherapy susceptibility, identifying high risk vascular surgical patients, non-alcoholic fatty liver disease, Alzheimer's disease and, in one of the earliest publications in the subject, as a diagnostic marker for appendicitis [

      Mallappa S, Sinha A, Gupta S, Chadwick S. Preoperative neutrophil lymphocyte ratio greater than five is a prognostic factor for recurrent colorectal cancer. Colorectal Dis, 2012, http://dx.doi.org/10.1111/codi.12008.

      ,
      • Sato H.
      • Tsubosa Y.
      • Kawano T.
      Correlation between the pretherapeutic neutrophil to lymphocyte ratio and the pathologic response to neoadjuvant chemotherapy in patients with advanced esophageal cancer.
      ,
      • Bhutta H.
      • Agha R.
      • Wong J.
      • Tang T.Y.
      • Wilson Y.G.
      • Walsh S.R.
      Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: a cross-sectional study.
      ,
      • Alkhouri N.
      • Morris-Stiff G.
      • Campbell C.
      • et al.
      Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease.
      ,
      • Kuyumcu M.E.
      • Yesil Y.
      • Oztȕrk Z.A.
      • et al.
      The evaluation of neutrophil-lymphocyte ratio in Alzheimer’s disease.
      ,
      • Goodman D.A.
      • Goodman C.B.
      • Monk J.S.
      Use of the neutrophil:lymphocyte ratio in the diagnosis of appendicitis.
      ].

      Keywords

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      References

        • Arbel Y.
        • Finkelstein A.
        • Halkin A.
        • et al.
        Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography.
        Atherosclerosis. 2012; 225: 456-460
      1. Pubmed Health. National Library of medicine (US) [Online] Available at: http://www.ncbi.nlm.nih.gov/pubmed?term=neutrophil%20lymphocyte%20ratio [accessed 10.01.12].

      2. Mallappa S, Sinha A, Gupta S, Chadwick S. Preoperative neutrophil lymphocyte ratio greater than five is a prognostic factor for recurrent colorectal cancer. Colorectal Dis, 2012, http://dx.doi.org/10.1111/codi.12008.

        • Sato H.
        • Tsubosa Y.
        • Kawano T.
        Correlation between the pretherapeutic neutrophil to lymphocyte ratio and the pathologic response to neoadjuvant chemotherapy in patients with advanced esophageal cancer.
        World J Surg. 2012; 36: 617-622
        • Bhutta H.
        • Agha R.
        • Wong J.
        • Tang T.Y.
        • Wilson Y.G.
        • Walsh S.R.
        Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: a cross-sectional study.
        Vasc Endovascular Surg. 2011; 45: 227-231
        • Alkhouri N.
        • Morris-Stiff G.
        • Campbell C.
        • et al.
        Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease.
        Liver Int. 2012; 32: 297-302
        • Kuyumcu M.E.
        • Yesil Y.
        • Oztȕrk Z.A.
        • et al.
        The evaluation of neutrophil-lymphocyte ratio in Alzheimer’s disease.
        Dement Geriatr Cogn Disord. 2012; 34: 69-74
        • Goodman D.A.
        • Goodman C.B.
        • Monk J.S.
        Use of the neutrophil:lymphocyte ratio in the diagnosis of appendicitis.
        Am Surg. 1995; 61: 257-259
        • Imtiaz F.
        • Shafique K.
        • Mirza S.S.
        • Ayoob Z.
        • Vart P.
        • Rao S.
        Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population.
        Int Arch Med. 2012; 5: 2
        • Siminiak T.
        • Flores N.
        • Sheridan D.
        Neutrophil interactions with endothelium and platelets: possible role in the development of cardiovascular.
        Eur Heart J. 1995; 16: 160-170
        • Ott I.
        • Neumann F.J.
        • Gawaz M.
        • Schmitt M.
        • Schömig A.
        Increased neutrophil-platelet adhesion in patients with unstable angina.
        Circulation. 1996; 94: 1239-1246
        • Tamhane U.U.
        • Aneja S.
        • Montgomery D.
        • Rogers E.K.
        • Eagle K.A.
        • Gurm H.S.
        Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome.
        Am J Cardiol. 2008; 102: 653-657
        • Park B.-J.
        • Shim J.-Y.
        • Lee H.-R.
        • et al.
        Relationship of neutrophil-lymphocyte ratio with arterial stiffness and coronary calcium score.
        Clin Chim Acta. 2011; 412: 925-929
        • Chen T.M.
        • Lin C.C.
        • Huang P.T.
        • Wen C.F.
        Neutrophil-to-lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation.
        J Gastroenterol Hepatol. 2012; 27: 553-561
        • Thavaramara T.
        • Phaloprakarn C.
        • Tangitgamol S.
        • Manusirivithaya S.
        Role of neutrophil to lymphocyte ratio as a prognostic indicator of epithelial ovarian cancer.
        J Med Assoc Thai. 2011; 94: 871-877
        • Cedrés S.
        • Torrejon D.
        • Martínez A.
        • et al.
        Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV non-small cell lung cancer.
        Clin Transl Oncol. 2012; 14: 864-869
        • Rashid F.
        • Waraich N.
        • Bhatti I.
        • et al.
        A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection.
        World J Surg Oncol. 2010; 8: 1

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