Abstract
Objective
Individual cardiovascular disease (CVD) risk factors are associated with dementia.
For the first time, we investigated whether the Framingham CVD risk score–which comprises
these multiple risk factors–was also associated with future dementia risk.
Methods
Individual participant meta-analysis of two large, general population cohort studies
(N = 11,887). For the purposes of comparison of the dementia results, we also examined
the association between the Framingham CVD risk score and CVD-related death.
Results
Framingham CVD risk score was associated with dementia death (hazard ratio per 10%
increased risk, 95% confidence interval: 4.00, 2.44–6.56). Adjusting for age eliminated
this association (1.04, 0.53–2.01); similarly, age explained 88% of the ability of
the Framingham CVD risk score to predict CVD death.
Conclusions
The Framingham CVD risk score was no more strongly associated with future dementia
than age. It therefore offers no added value in predicting dementia.
Keywords
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Article info
Publication history
Published online: March 14, 2013
Accepted:
February 11,
2013
Received in revised form:
January 30,
2013
Received:
December 20,
2012
Identification
Copyright
© 2013 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
