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Response to “Adjusting for brachial artery diameter in the analysis of flow-mediated dilatation: Pitfalls of a landmark paper?”

      We thank Woodman and Mangoni [
      • Woodman R.J.
      • Mangoni A.A.
      Adjusting for brachial artery diameter in the analysis of flow-mediated dilation: pitfalls of a landmark paper?.
      ] for their interest in our study of the percentage flow-mediated dilation (FMD%) statistic and its dependency on baseline artery diameter (Dbase) [
      • Atkinson G.
      • Batterham A.M.
      Allometric scaling of diameter change in the original flow-mediated dilation protocol.
      ]. We can respond to the three main points as follows.

      Keywords

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      References

        • Woodman R.J.
        • Mangoni A.A.
        Adjusting for brachial artery diameter in the analysis of flow-mediated dilation: pitfalls of a landmark paper?.
        Atherosclerosis. 2013; 228: 277-279
        • Atkinson G.
        • Batterham A.M.
        Allometric scaling of diameter change in the original flow-mediated dilation protocol.
        Atherosclerosis. 2013; 226: 425-427
        • Vickers A.J.
        The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study.
        BMC Med Res Meth. 2001; 1: 6
        • Senn S.
        Testing for baseline differences in clinical trials.
        Stat Med. 1994; 13: 1715-1726
        • Celermajer D.S.
        • Sorensen K.E.
        • Gooch V.M.
        • et al.
        Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis.
        Lancet. 1992; 340: 1111-1115
        • Yeboah J.
        • Crouse J.R.
        • Hsu F.-C.
        • Burke G.L.
        • Herrington D.M.
        Brachial flow-mediated dilation predicts incident cardiovascular events in older adults. The cardiovascular Health study.
        Circulation. 2007; 115: 2390-2397
        • Charakida M.
        • Masi S.
        • Luscher T.F.
        • Kastelein J.J.P.
        • Deanfield J.E.
        Assessment of atherosclerosis: the role of flow-mediated dilatation.
        Eur Heart J. 2010; 31: 2854-2861
        • Shrier I.
        • Platt R.W.
        Reducing bias through directed acyclic graphs.
        BMC Med Res Meth. 2008; 8: 70

      Linked Article

      • Adjusting for brachial artery diameter in the analysis of flow-mediated dilatation: Pitfalls of a landmark paper?
        AtherosclerosisVol. 228Issue 1
        • Preview
          Since the publication of the landmark paper by Celermajer et al. on the use of brachial artery ultrasound to measure flow-mediated dilatation (FMD) some 20 years ago [1], researchers have enthusiastically adopted the non-invasive technique as a way to assess endothelial function (EF). Impaired EF is an indicator of pre-clinical cardiovascular risk [1] and predictor of future CV events [2]. Although the method is now well established, several alternative approaches are often applied to the analysis of FMD.
        • Full-Text
        • PDF
      • Allometric scaling of diameter change in the original flow-mediated dilation protocol
        AtherosclerosisVol. 226Issue 2
        • Preview
          The negative correlation between percent flow-mediated dilation (FMD%) and baseline diameter (Dbase) has only recently been recognised as a fundamental ratio-scaling problem, which is not resolved by significance-testing of Dbase inequality between groups/conditions, nor by covariate-adjusting FMD% itself by Dbase. It is resolved appropriately by allometric scaling of the relationship between peak diameter (Dpeak) and Dbase using statistical models. Therefore, we extracted data from a seminal study on FMD%, and re-analysed it using allometric methods.
        • Full-Text
        • PDF