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Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids

  • Sridevi Devaraj
    Affiliations
    Department of Pathology and Immunology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA
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  • Alexander Chien
    Affiliations
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
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  • Bhavana Rao
    Affiliations
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
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  • Xinpu Chen
    Affiliations
    Department of Pathology and Immunology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA
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  • Ishwarlal Jialal
    Correspondence
    Corresponding author. Laboratory for Atherosclerosis and Metabolic Research, 4635 2nd Avenue, Research I Bldg, Room 3005, UC Davis Medical Center, Sacramento, CA, USA. Tel.: +1 916 734 6592; fax: +1 916 734 6593.
    Affiliations
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA

    Veterans Affairs Medical Center, Mather, CA, USA
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      Abstract

      Endothelial dysfunction is pivotal in atherosclerosis. Endothelial progenitor cells (EPC) predict cardiovascular events and could serve as a cellular biomarker of endothelial function. Epidemiological studies suggest the benefits of omega 3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on cardiovascular health. However, there is a paucity of data on the effect of n-3 PUFA on EPC number and functionality. Incubation with DHA and EPA, either alone or in combination significantly increased the number of EPCs and colony forming units (CFU). In addition, co-incubation with DHA + EPA, significantly enhanced EPC migratory capacity, adhesive properties and greater incorporation into tubules. Thus, EPA + DHA are effective in improving EPC number and functionality in-vitro. Future studies will test the effect of n-3 PUFA supplementation on EPC number and function in-vivo and will elucidate plausible mechanisms.

      Keywords

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