Highlights
- •Egg consumption increases the risk of cardiovascular diseases in a dose–response manner, especially in patients with diabetes.
- •There is a dose–response positive relationship between egg consumption and the risk of diabetes.
- •Individuals in other western countries seem to have a higher risk of cardiovascular diseases than the ones in the USA under high egg consumption.
Abstract
Objectives
To assess the dose–response relationship between egg consumption and the risk of cardiovascular
diseases (CVD) and diabetes.
Methods
We systematically searched MEDLINE database through December 2012. Fixed- or random-effects
model was used to pool the relative risks (RRs) and their 95% confidence intervals
(CIs). Subgroup analyses was performed to explore the potential sources of heterogeneity.
Weighted linear regression model was used to estimate the dose–response relationship.
Results
Fourteen studies involving 320,778 subjects were included. The pooled RRs of the risk
of CVD, CVD for separated diabetes patients, and diabetes for the highest vs lowest
egg intake were 1.19 (95% CI 1.02–1.38), 1.83 (95% CI 1.42–2.37), 1.68 (95% CI 1.41–2.00),
respectively. For each 4/week increment in egg intake, the RRs of the risk for CVD,
CVD for separated diabetes patients, diabetes was 1.06 (95% CI 1.03–1.10), 1.40 (95%
CI 1.25–1.57), 1.29 (95% CI 1.21–1.37), respectively. Subgroup analyses showed that
population in other western countries have increased CVD than ones in USA (RR 2.00,
95% CI 1.14 to 3.51 vs 1.13, 95% CI 0.98 to 1.30, P = 0.02 for subgroup difference).
Conclusions
Our study suggests that there is a dose–response positive association between egg
consumption and the risk of CVD and diabetes.
Keywords
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Article Info
Publication History
Published online: May 06, 2013
Accepted:
April 2,
2013
Received in revised form:
March 9,
2013
Received:
February 8,
2013
Identification
Copyright
© 2013 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
