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The formation of monocyte-platelet aggregates in stirred whole blood in response to different platelet agonists

      Introduction: Using in vitro and in vivo models of vascular inflammation resembling aspects of the chronic inflammatory environment, we have recently described a paradigm where platelets recruited to intact endothelial monolayers form adhesive bridges between the vessel wall where they preferentially aid monocyte recruitment. It is well documented that monocyte-platelet aggregates form in circulating blood with increased incidence in patients with cardiovascular and chronic inflammatory disease. It is unknown whether heterotypic aggregation increases efficiency of monocyte recruitment during vascular inflammation, which we will investigate in the near future. The aim of the current study was to determine how efficiently monocyte-platelet aggregates could form in whole blood in response to different platelet agonists.
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