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Low density lipoprotein aggregated by sphingomyelinase is internalised by macrophages and oxidised in lysosomes

      Background: Large trials of antioxidants to inhibit low density lipoprotein (LDL) oxidation have failed to protect against cardiovascular disease. We have shown that LDL aggregated by vortexing is internalised by macrophages and oxidised by iron in lysosomes. This raises the novel possibility that antioxidants targetting lysosomes might be a therapy for atherosclerosis.
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