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Oxidised LDL activates platelet NADPH oxidase through CD36 to promote thrombosis

  • S.G. Magwenzi
    Correspondence
    Presenting author
    Affiliations
    Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Thrombosis Research Laboratory, Lab 013/014, Hardy Building, University of Hull, Cottingham Road, Hull HU6 7RX, UK
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  • C. McNeil
    Affiliations
    Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Thrombosis Research Laboratory, Lab 013/014, Hardy Building, University of Hull, Cottingham Road, Hull HU6 7RX, UK
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  • K. Wraith
    Affiliations
    Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Thrombosis Research Laboratory, Lab 013/014, Hardy Building, University of Hull, Cottingham Road, Hull HU6 7RX, UK
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  • K.M. Naseem
    Affiliations
    Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Thrombosis Research Laboratory, Lab 013/014, Hardy Building, University of Hull, Cottingham Road, Hull HU6 7RX, UK
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      Rationale: Oxidised low-density lipoproteins (oxLDL) activate blood platelets through undefined mechanisms. Here we examined the contribution of endogenous reactive oxygen species (ROS) to platelet activation and thrombosis induced by oxLDL.
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