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A new role for the regulator of g-protein signalling-1 in inflammatory cell function in angiotensin II-induced aortic aneurysm formation

      The Regulator of G-Protein Signalling-1 (RGS1) acts to down-regulate chemokine receptor signalling. Studies in our laboratory have shown it to be up-regulated in ApoE-/- mice in association with atherosclerotic plaque progression and with monocyte-macrophage activation; however an in vivo role for RGS-1 in macrophage function has not been investigated.
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