Highlights
- •Coronary artery calcium (CAC) prevalence was similar among South Asian & White men.
- •CAC was higher in South Asian men than African American, Latino and Chinese men.
- •South Asian women had similar CAC prevalence compared to all MESA women.
- •South Asian women ≥70 years had higher CAC prevalence than all other women.
Abstract
Objectives
South Asians (individuals from India, Pakistan, Bangladesh, Nepal, and Sri Lanka)
have high rates of cardiovascular disease which cannot be explained by traditional
risk factors. Few studies have examined coronary artery calcium (CAC) in South Asians.
Methods
We created a community-based cohort of South Asians in the United States and compared
the prevalence and distribution of CAC to four racial/ethnic groups in the Multi-Ethnic
Study of Atherosclerosis (MESA). We compared 803 asymptomatic South Asians free of
cardiovascular disease to the four MESA racial/ethnic groups (2622 Whites, 1893 African
Americans, 1496 Latinos and 803 Chinese Americans).
Results
The age-adjusted prevalence of any CAC was similar between White and South Asian men,
but was lower in South Asian women compared to White women. After adjusting for all
covariates associated with CAC, South Asian men were similar to White men and had
higher CAC scores compared to African Americans, Latinos and Chinese Americans. In
fully adjusted models, CAC scores were similar for South Asian women compared to all
women enrolled in MESA. However, South Asian women ≥70 years had a higher prevalence
of any CAC than most other racial/ethnic groups.
Conclusions
South Asian men have similarly high CAC burden as White men, but higher CAC than other
racial/ethnic groups. South Asian women appear to have similar CAC burden compared
to other women, but have somewhat higher CAC burden in older age. The high burden
of subclinical coronary atherosclerosis in South Asians may partly explain higher
rates of cardiovascular disease in South Asians.
Keywords
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Article info
Publication history
Published online: February 28, 2014
Accepted:
February 14,
2014
Received in revised form:
February 8,
2014
Received:
January 2,
2014
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Corrigendum to ‘Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: The MASALA and MESA studies’ [Atherosclerosis 234 (2014) 102–107]AtherosclerosisVol. 235Issue 1
- PreviewThe authors regret an error within the published version of Fig. 1 in the above paper, which showed smoothed estimates of mean CAC scores by age for each sex and race/ethnic group, obtained under an inappropriate assumption of log-normality. To correct this error, we have now used quantile regression to regress the CAC scores on a 3-knot restricted cubic spline by age and plotted the resulting smoothed estimates of median CAC scores against age for each race/ethnic subgroup. As before, the figure imposes smoothness and extrapolates an increasing trend for the oldest age groups.
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