Objectives: HIV-1 Nef is a pleiotropic modulator of various cellular cell surface receptors. Our lab has established that HIV reduces cholesterol efflux, a major mechanism of atheroprotection, in peripheral tissues through the action of Nef. Nef impairs the functionality of ABCA1 and induces ABCA1 degradation. In these studies we investigated the mechanism of this Nef activity.
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© 2014 Published by Elsevier Inc.