Metabolism and functions of lipids in vascular cells| Volume 235, ISSUE 2, e21, August 2014

HIV-1 protein Nef impairs cellular cholesterol efflux by disrupting the interaction between abca1 and calnexin

      Objectives: HIV-1 Nef is a pleiotropic modulator of various cellular cell surface receptors. Our lab has established that HIV reduces cholesterol efflux, a major mechanism of atheroprotection, in peripheral tissues through the action of Nef. Nef impairs the functionality of ABCA1 and induces ABCA1 degradation. In these studies we investigated the mechanism of this Nef activity.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect