04 - Endothelial cell biology and angiogenesis| Volume 235, ISSUE 2, e29, August 2014

Augmented neovascularization capacities of endothelial progenitor cells via anti-apoptotic effect by FOXO4 sirna transfection in rats

      Objectives: The effects of therapeutic angiogenesis by intramuscular injection of early pro-angiogenic cells (EPCs) into the ischemic limbs are unsatisfactory. The limb tissue may retain the ischemia-induced oxidative stress and hence lead apoptosis of injected EPCs, resulting in suboptimal clinical effects. It has been reported that Forkhead transcription factor 4 (FOXO4) plays a pivotal role in apoptosis signaling of EPCs in response to oxidative stress. Accordingly, we assessed whether FOXO4-knockdown EPCs (FOXO4KD-EPCs) could suppress the oxidative stress-induced apoptosis and augment the neovascularization capacity in ischemic limbs.
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