29 - HDL structure and function| Volume 235, ISSUE 2, e45-e46, August 2014

Incubation of MDCO216 with human serum potentiates ABCA1 mediated cholesterol efflux capacity and generates new prebeta-1 Hdl

      Objectives: MDCO216 is a complex of dimeric apoA-IMilano (apoA-IM) and POPC, shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO216 on cholesterol efflux capacity from J774 cells, as well as on various HDL subfractions measured by ELISA, 2D-electrophoresis and NMR.
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