Significant accumulation of oxLDL/beta2-glycoprotein i complexes in arterial lesions of whhl rabbits: PET/CT imaging using an auto antibody's scFv variant

      Objectives: The oxidative modification of LDL and its interaction with β2-glycoprotein I (oxLDL/β2GPI complexes) in the arterial walls play a central role in the development of atherosclerotic lesions. We have developed a IgG antibody specific for oxLDL/βGPI complexes to be used as an immunologic probe for the non-invasive detection of atherosclerotic plaques. The aim of the study was to assess the clinical utility of a variant of the antibody as a PET/CT in vivo imaging probe in the diagnosis and management for atherothrombotic cardiovascular diseases (CVD), as well as to clarify its atherogenic role.
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