Objectives: Streptococcal serum opacity factor (SOF) disrupts high density lipoprotein (HDL) structure in vitro and in vivo giving rise to a neo HDL, a cholesteryl ester-rich micro emulsion and lipid free apo A-I. In WT C57/BL mice, SOF (4 microg) reduces serum cholesterol ∼45% in three h where it remains for at least 20 h. Early evidence suggested that HDL instability and apo A-I lability were required for the SOF reaction. The goal of this study was to identify the role of apo A-I in the SOF reaction in vitro and in vivo.
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© 2014 Published by Elsevier Inc.