Objectives: Inflammation is associated with low serum HDL cholesterol and apolipoprotein A-I (apoA-I) levels probably due to increased catabolism and remodeling of HDL. The exact mechanisms that lead to low HDL during inflammation remain unclear. Matrix metalloproteinases (MMPs) are involved in inflammation and are present in atherosclerotic lesions. The aim of our study was to investigate whether MMP-8 causes structural changes in apoA-I and HDL particles and thereby affects apoA-I-mediated cholesterol efflux.
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© 2014 Published by Elsevier Inc.