29 - HDL structure and function| Volume 235, ISSUE 2, e173, August 2014

Matrix metalloproteinase 8 cleaves apolipoprotein a-i and reduces its cholesterol efflux capacity

      Objectives: Inflammation is associated with low serum HDL cholesterol and apolipoprotein A-I (apoA-I) levels probably due to increased catabolism and remodeling of HDL. The exact mechanisms that lead to low HDL during inflammation remain unclear. Matrix metalloproteinases (MMPs) are involved in inflammation and are present in atherosclerotic lesions. The aim of our study was to investigate whether MMP-8 causes structural changes in apoA-I and HDL particles and thereby affects apoA-I-mediated cholesterol efflux.
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