33 - Cholesterol efflux and reverse cholesterol transport| Volume 235, ISSUE 2, e181, August 2014

Evaluation of serum cholesterol efflux capacity in diabetic compared to healthy subjects

      Objectives: HDL provide cardiovascular protection by promoting reverse cholesterol transport (RCT). Efflux of cell cholesterol to HDL, the first step of RCT, can occur through aqueous diffusion, SR-BI, ABCG1 and ABCA1. Serum cholesterol efflux capacity (CEC), an index of HDL functionality, depends of HDL levels but is also strictly related to HDL composition. The aim of this study is to measure serum CEC in patients with diabetic dyslipidemia (DD) (n=116) and in apparently healthy control subjects (HS) (n=94) and to correlate serum CEC with preclinical atherosclerosis (IMT).
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