33 - Cholesterol efflux and reverse cholesterol transport| Volume 235, ISSUE 2, e182, August 2014

In vivo acute systemic inflammation affects hdl cholesterol efflux capacity

      Objectives: One of the primary antiatherogenic properties of HDL is its role in promoting reverse cholesterol transport (RCT). The capacity of serum HDL to promote efflux of cholesterol from cells (cholesterol efflux capacity, CEC) represents an index of HDL functionality and its evaluation serves to estimate the efficiency of the entire process in humans. It has been suggested that HDL functionality changes may contribute to cardiovascular disease protection. Inflammation is a central feature during all stages of atherosclerotic plaque formation with cytokines/chemokines orchestrating the influx of immune cells in disease vessels. Indeed, systemic inflammatory diseases have been associated with an increased cardiovascular risk. The objective of this study was to analyze whether acute systemic inflammatory disease may affects the capacity of HDL to promote cholesterol efflux through the main pathways, (aqueous diffusion (AD), the scavenger receptor-BI (SR-BI) and the ATP binding cassette transporters A1 (ABCA1) and G1 (ABCG1)).
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