Objectives: The accumulation of cholesteryl ester (CE)-rich lipid droplets (LD) is a hallmark feature of foam cells formation in atherosclerosis. The ABCA1-mediated efflux of free cholesterol (FC) is crucial for removal of excess cholesterol. Using cholesterol-loaded primary bone marrow- derived and peritoneal mouse macrophages, Yves Marcel's team reported that autophagy mediated the delivery of cytosolic LD to lysosomes and that Acid CE Hydrolases (aCEH) degrades LD-CE to generate FC for efflux. Our goal was to compare the involvement of autophagy in cholesterol efflux between lipid-loaded J774 mouse macrophage cell line and primary cultures of human monocyte-derived macrophages (HMDM).
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Atherosclerosis
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
© 2014 Published by Elsevier Inc.