Objectives: The accumulation of cholesteryl ester (CE)-rich lipid droplets (LD) is a hallmark
feature of foam cells formation in atherosclerosis. The ABCA1-mediated efflux of free
cholesterol (FC) is crucial for removal of excess cholesterol. Using cholesterol-loaded
primary bone marrow- derived and peritoneal mouse macrophages, Yves Marcel's team
reported that autophagy mediated the delivery of cytosolic LD to lysosomes and that
Acid CE Hydrolases (aCEH) degrades LD-CE to generate FC for efflux. Our goal was to
compare the involvement of autophagy in cholesterol efflux between lipid-loaded J774
mouse macrophage cell line and primary cultures of human monocyte-derived macrophages
(HMDM).
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Publication history
EAS-0084
Identification
Copyright
© 2014 Published by Elsevier Inc.
