Objectives: Reactive dicarbonyls seems to be a common product of both carbonyl and oxidative
stress and their biogenesis is related to glycemic and lipid status in diabetes. Excessive
generation of dicarbonyls leads to production of advanced glycation end products (AGE),
activates inflammatory pathway, increases oxidative stress and can play a key role
in the development of diabetic vascular complications. Dicarbonyls determination could
be early biomarker risk for these complications. The effect of dyslipidemia on dicarbonyl
stress is not fully clarified. In our study we analyzed level of individual reactive
dicarbonyls – methylglyoxal (MG), glyoxal (GL) and 3-deoxyglucosone (3-DG) in relation
to parameters of oxidative stress and lipid disorders in non-obese rats with hereditary
hypertriglyceridemia (HHTg rats).
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EAS-0651
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© 2014 Published by Elsevier Inc.
