37 - Diabetes, insulin sensitivity and resistance| Volume 235, ISSUE 2, e191, August 2014

The effect of hypertriglyceridemia on carbonyl and oxidative stress in an experimental model of insulin resistance

      Objectives: Reactive dicarbonyls seems to be a common product of both carbonyl and oxidative stress and their biogenesis is related to glycemic and lipid status in diabetes. Excessive generation of dicarbonyls leads to production of advanced glycation end products (AGE), activates inflammatory pathway, increases oxidative stress and can play a key role in the development of diabetic vascular complications. Dicarbonyls determination could be early biomarker risk for these complications. The effect of dyslipidemia on dicarbonyl stress is not fully clarified. In our study we analyzed level of individual reactive dicarbonyls – methylglyoxal (MG), glyoxal (GL) and 3-deoxyglucosone (3-DG) in relation to parameters of oxidative stress and lipid disorders in non-obese rats with hereditary hypertriglyceridemia (HHTg rats).
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect