69 - Anti-infammatory therapies| Volume 235, ISSUE 2, e267, August 2014

Intervention with anti-inflammatory RVE1 attenuates atherosclerosis without decreasing plasma cholesterol and adds to the anti-atherogenic effect of atorvastatin

      Objectives: Atherosclerosis is a multifactorial disease that correlates positively and significantly with low-density lipoprotein (LDL) plasma cholesterol and requires inflammatory components. Whereas reduction of plasma LDL cholesterol is effectively achieved by statins, quenching of the inflammatory factors has not been addressed adequately by existing therapies. Resolvins are naturally-occurring, small molecule lipid mediators with the potential to treat multiple inflammatory diseases. Here we investigated the potency of ω-3 fatty acid eicosapentaenoic acid derived resolvin E1 (RvE1) in attenuating atherosclerosis in a humanized mouse model for atherosclerosis, ApoE*3 Leiden transgenic mice
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