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Serum coenzyme Q10 and risk of disabling dementia: The Circulatory Risk in Communities Study (CIRCS)

      Abstract

      Objective: To examine whether coenzyme Q10, a potent antioxidant, is associated with risk of dementia, which has not yet been elucidated. Approach and results: We performed a case–control study nested in a community-based cohort of approximately 6000 Japanese aged 40–69 years at baseline (1984–1994). Serum coenzyme Q10 was measured in 65 incident cases of disabling dementia with dementia-related behavioral disturbance or cognitive impairment incident between 1999 and 2004, and in 130 age-, sex- and baseline year-matched controls. Serum coenzyme Q10 was inversely associated with dementia: the multivariate odds ratios (95% confidence intervals) were 0.68 (0.26–1.78), 0.92 (0.33–2.56), and 0.23 (0.06–0.86) for individuals with the second, third, and highest quartiles of coenzyme Q10, respectively, as compared with the lowest quartile (P for trend = 0.05). A similar association was found for the coenzyme Q10/total cholesterol ratio: the respective ORs were 0.67 (0.25–1.78), 0.73 (0.28–1.92), and 0.21 (0.05–0.90) (P for trend = 0.04). Conclusions: Serum coenzyme Q10 levels were inversely associated with risk of disabling dementia.

      Keywords

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