- •Subendothelial LDL-adhesion is a key event in the atherosclerotic lesion formation.
- •During oxidation aldehydes could leak out of the LDL-particle and modify nearby matrix proteins.
- •Aldehyde-collagen type IV correlated with oxidized LDL and was increased in symptomatic lesions.
- •Aldehyde-modification of collagen type IV decreased endothelial cell attachment.
- •Aldehyde-modification of collagen type IV may cause endothelial dysfunction and increase the risk of clinical events.
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