Highlights
- •We analysed proinflammatory monocytes/macrophages in perirenal and perivascular fat.
- •We found no differences in the monocyte/macrophage content between men and women.
- •The highest proportion of double positive CD14+CD16+ cells was found in older women.
- •Correlation of monocyte/macrophage content with age was found only in older women.
- •CD14+CD16+ monocytes/macrophages should be evaluated according to the sex and age.
Abstract
The presence of proinflammatory monocytes/macrophages (CD14+CD16+) has been documented
in conditions of inflammation, such as atherosclerosis. We analysed the proportion
of proinflammatory monocytes/macrophages in perirenal and perivascular fat in healthy
living kidney donors with regard to sex and age reflecting reproductive status in
women; therefore, women were further divided to younger and older group (younger and
older than 51 years) reflecting potential age of menopause. Monocyte/macrophages were
identified as CD14+ mononuclear cells and divided into subpopulations based on the
co-expression of CD16. We found no differences in the monocyte/macrophage content
between men (n = 15) and women (n = 28). Conversely, we observed a higher proportion
of double positive CD14+CD16+ monocytes/macrophages in older women (n = 14) compared
to younger women (n = 14). In addition, a strong correlation was found between the
monocyte/macrophage content in fat and age only in older women. Therefore, proinflammatory
monocytes/macrophages (CD14+CD16+) should be evaluated according to the sex and age.
Keywords
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Article info
Publication history
Published online: March 17, 2015
Accepted:
March 8,
2015
Received in revised form:
March 5,
2015
Received:
November 1,
2014
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
ScienceDirect
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