- •We analysed proinflammatory monocytes/macrophages in perirenal and perivascular fat.
- •We found no differences in the monocyte/macrophage content between men and women.
- •The highest proportion of double positive CD14+CD16+ cells was found in older women.
- •Correlation of monocyte/macrophage content with age was found only in older women.
- •CD14+CD16+ monocytes/macrophages should be evaluated according to the sex and age.
The presence of proinflammatory monocytes/macrophages (CD14+CD16+) has been documented in conditions of inflammation, such as atherosclerosis. We analysed the proportion of proinflammatory monocytes/macrophages in perirenal and perivascular fat in healthy living kidney donors with regard to sex and age reflecting reproductive status in women; therefore, women were further divided to younger and older group (younger and older than 51 years) reflecting potential age of menopause. Monocyte/macrophages were identified as CD14+ mononuclear cells and divided into subpopulations based on the co-expression of CD16. We found no differences in the monocyte/macrophage content between men (n = 15) and women (n = 28). Conversely, we observed a higher proportion of double positive CD14+CD16+ monocytes/macrophages in older women (n = 14) compared to younger women (n = 14). In addition, a strong correlation was found between the monocyte/macrophage content in fat and age only in older women. Therefore, proinflammatory monocytes/macrophages (CD14+CD16+) should be evaluated according to the sex and age.
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- Natural postmenopause is associated with an increase in combined cardiovascular risk factors.Physiol. Res. 2012; 61: 587-596
- Menopause: clustering of metabolic syndrome components and population changes in insulin resistance.Climacteric. 2011; 14: 83-91
- Blood pressure around the menopause: a population study.J. Hypertens. 2008; 26: 1976-1982
- From blood monocytes to adipose tissue–resident macrophages induction of diapedesis by human mature adipocytes.Diabetes. 2004; 53: 1285-1292
- The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue.Vasc. Pharmacol. 2010; 52: 27-36
- Adipose tissue macrophages: their role in adipose tissue remodeling.J. Leukoc. Biol. 2010; 88: 1-7
- The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients.Blood. 1993; 82: 3170-3176
- Investigating the role of proinflammatory CD16+ monocytes in the pathogenesis of inflammatory bowel disease.Clin. Exp. Immunol. 2010; 161: 332-341
- The role of monocytes in atherosclerotic coronary artery disease.Ann. Med. 2010; 42: 394-403
- The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF.J. Immunol. 2002; 168: 3536-3542
- SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset.Blood. 2011; 118: e50-e61
- Longitudinal trends in major cardiovascular risk factors in the Czech population between 1985 and 2007/8. Czech MONICA and Czech post-MONICA.Atherosclerosis. 2010; 211: 676-681
- Effect of different types of dietary fatty acids on subclinical inflammation in humans.Physiol. Res. 2013; 62: 145-152
- Proinflammatory status, genetics and atherosclerosis.Physiol Res. 2009; 58: S111-s118
- Quantification of intra-abdominal fat during controlled weight reduction: assessment using the water-suppressed breath-hold MRI technique.Physiol. Res. 2004; 53: 229-234
- Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness.Clin. Exp. Hypertens. A. 1991; 13: 277-296
- Crosstalk between perivascular adipose tissue and blood vessels.Curr. Opin. Pharmacol. 2010; 10: 191-196
- Perivascular adipose tissue: more than just structural support.Clin. Sci. (Lond). 2012; 122: 1-12
- Remodeling phenotype of human subcutaneous adipose tissue macrophages.Circulation. 2008; 117: 806-815
- Macrophage-mediated inflammation in metabolic disease.Nat. Rev. Immunol. 2011; 11: 738-749
- Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham heart study.Atherosclerosis. 2010; 210: 656-661
- Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis.Arterioscler. Thromb. Vasc. Biol. 2009; 29: 781-786
- Diagnostic and prognostic potential of the macrophage specific receptor CD163 in inflammatory diseases.Inflamm. Allergy Drug Targets. 2013; 12: 391-402
- Macrophage activation and polarization: nomenclature and experimental guidelines.Immunity. 2014; 41: 14-20
Published online: March 17, 2015
Accepted: March 8, 2015
Received in revised form: March 5, 2015
Received: November 1, 2014
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
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