Highlights
- •Insuline resistance and subclinical inflammation have a key role in pathogenesis of non-alcoholic fatty liver disease.
- •Non-alcoholic fatty liver disease is associated with atherosclerosis.
- •Measurement of arterial stifness, intima media thickness, and endothelial function is predictor for cardiovascular disease.
- •The association between NAFLD and atherosclerosis is independent of cardiovascular risk factors and presence of Mets.
Abstract
Introduction
The possible cause of accelerated atherosclerosis in NAFLD may be the relationship
with the MetS and its components. Our primary goal was to evaluate the relationship
between NAFLD and subclinical atherosclerosis in adult male patients between 20 and
40 years of age. Moreover, we aimed to investigate the changes in this association
according to the presence or absence of MetS.
Method
Sixty-one male patients with biopsy-proven NAFLD and 41 healthy male volunteers were
enrolled. In order to exclude any interference of confounding factors, we studied
a specifically selected group with no additional cardiovascular risk. PWV, CIMT and
FMD levels were measured in all patients and controls.
Results
The levels of cf-PWV were significantly higher in SS and NASH patients compared to
the control group (P < 0.001); no significant difference was found between SS and
NASH patients (P > 0.05). We found significantly decreased FMD levels in patients
with SS and NASH compared with control subjects (P < 0.001). Subjects with NASH had
significantly greater CIMT measurements than the SS and controls (P = 0.026, P < 0.001,
respectively). Although, NAFLD patients with MetS had increased cf-PWV and CIMT and
reduced FMD compared to healthy subjects (P < 0.05), no significant difference existed
between NAFLD with Mets and NAFLD without MetS in terms of cf-PWV, CIMT and FMD (P > 0.05)
Conclusion
The present study showed that the presence of NAFLD leads to increased risk of endothelial
dysfunction and atherosclerosis in adult male patients, independent of MetS.
Keywords
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Article info
Publication history
Published online: April 09, 2015
Accepted:
April 7,
2015
Received in revised form:
April 6,
2015
Received:
January 23,
2015
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
