Highlights
- •We present geometrically correct 3D OCT based on fusion of OCT and angiography.
- •3D OCT can accurately and reproducibly reconstruct coronary arteries and calculate ESS.
- •Combined functional and anatomical plaque assessment may predict high-risk plaque.
Abstract
Background
Geometrically-correct 3D OCT is a new imaging modality with the potential to investigate
the association of local hemodynamic microenvironment with OCT-derived high-risk features.
We aimed to describe the methodology of 3D OCT and investigate the accuracy, inter-
and intra-observer agreement of 3D OCT in reconstructing coronary arteries and calculating
ESS, using 3D IVUS and 3D QCA as references.
Methods-Results
35 coronary artery segments derived from 30 patients were reconstructed in 3D space
using 3D OCT. 3D OCT was validated against 3D IVUS and 3D QCA. The agreement in artery
reconstruction among 3D OCT, 3D IVUS and 3D QCA was assessed in 3-mm-long subsegments
using lumen morphometry and ESS parameters. The inter- and intra-observer agreement
of 3D OCT, 3D IVUS and 3D QCA were assessed in a representative sample of 61 subsegments
(n = 5 arteries). The data processing times for each reconstruction methodology were
also calculated. There was a very high agreement between 3D OCT vs. 3D IVUS and 3D
OCT vs. 3D QCA in terms of total reconstructed artery length and volume, as well as
in terms of segmental morphometric and ESS metrics with mean differences close to
zero and narrow limits of agreement (Bland–Altman analysis). 3D OCT exhibited excellent
inter- and intra-observer agreement. The analysis time with 3D OCT was significantly
lower compared to 3D IVUS.
Conclusions
Geometrically-correct 3D OCT is a feasible, accurate and reproducible 3D reconstruction
technique that can perform reliable ESS calculations in coronary arteries.
Keywords
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Article info
Publication history
Published online: April 13, 2015
Accepted:
April 6,
2015
Received in revised form:
March 15,
2015
Received:
January 29,
2015
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
