Response gene to complement-32 mediates C5b-9 induced proliferation and migration in endothelial cells

      Aim: Complement activation and assembly of sublytic C5b-9 induces proliferation of endothelial cells (EC) and of smooth muscle cells (SMC), both pivotal milestones of atherosclerosis. Sublytic C5b-9 induces the expression of Response Gene to Complement (RGC)-32, which we have characterized as novel cell-cycle regulator involved in cellular proliferation. We now aimed to delineate the mechanisms through which RGC-32 impacts upon C5b-9 induced EC proliferation and migration.
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