Advertisement

Response gene to complement-32 mediates C5b-9 induced proliferation and migration in endothelial cells

      Aim: Complement activation and assembly of sublytic C5b-9 induces proliferation of endothelial cells (EC) and of smooth muscle cells (SMC), both pivotal milestones of atherosclerosis. Sublytic C5b-9 induces the expression of Response Gene to Complement (RGC)-32, which we have characterized as novel cell-cycle regulator involved in cellular proliferation. We now aimed to delineate the mechanisms through which RGC-32 impacts upon C5b-9 induced EC proliferation and migration.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect