Abstract
Objective
It is unclear if vitamin D supplementation improves central blood pressure or arterial
stiffness in Native American (NA) women.
Methods
Healthy postmenopausal NA women were randomized to receive 400 IU or 2500 IU of vitamin
D for 6 months. Central systolic blood pressure (cSBP), central pulse pressure (cPP)
and aortic augmentation index (AIx) were estimated by tonometry at baseline and after
6 months.
Results
Study volunteers (n = 98) were 61 (7.3) years old. 25(OH)D was 26.4 (11.0) ng/mL.
25(OH)D was similar between the two treatment groups (p = 0.291), as were baseline
cSBP, cPP, and CVD risk factors (all p > 0.1). Treatment with 2500 IU of daily vitamin
D3 did not affect cSBP, cPP, or AIx (all p > 0.1) compared to 400 IU daily.
Conclusions
Despite low serum 25(OH)D at baseline, 6 months of vitamin D supplementation did not
improve central blood pressure parameters or arterial stiffness in NA women.
Clinical trials. gov identifier
NCT01490333.
Keywords
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Article info
Publication history
Published online: April 25, 2015
Accepted:
April 22,
2015
Received in revised form:
April 17,
2015
Received:
February 23,
2015
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
