- •Low 25(OH)D status was associated with increased risk of coronary disease in Whites.
- •No association of 25(OH)D with coronary heart disease was found in Blacks.
- •No interaction was found with genetic polymorphisms of vitamin D binding protein.
- •Further investigation into potential mechanisms for this racial difference is needed.
- •Whether treating low vitamin D can reduce coronary events is unknown.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Vitamin D deficiency.N. Engl. J. Med. 2007; 357: 266-281
- Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies.Circ. Cardiovasc Qual. Outcomes. 2012; 5: 819-829
- Vitamin D deficiency and risk of cardiovascular disease.Circulation. 2008; 117: 503-511
- Relationship of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general health care population.Am. J. Cardiol. 2010; 106: 963-968
- Vitamin D, race, and cardiovascular mortality: findings from a National US Sample.Ann. Fam. Med. 2010; 8: 11-18
- 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study.Arch. Intern. Med. 2008; 168: 1174-1180
- Racial differences in the association of serum 25-hydroxyvitamin D concentration with coronary heart disease events.JAMA. 2013; 310: 179-188
- Vitamin D, calcium, and atherosclerotic risk – evidence from serum levels and supplementation studies.Curr. Atheroscler. Rep. 2013; 15: 293
- The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease.Contemp. Clin. Trials. 2012; 33: 159-171
- 25-hydroxyvitamin D deficiency is associated with fatal stroke among whites but not blacks: the nhanes-iii linked mortality files.Nutrition. 2012; 28: 367-371
- Vitamin D-binding protein and vitamin D status of black Americans and white Americans.N. Engl. J. Med. 2013; 369: 1991-2000
- Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein.J. Clin. Endocrinol. Metab. 1986; 63: 954-959
- investigators. The atherosclerosis risk in communities (aric) study: design and objectives. The aric investigators.Am. J. Epidemiol. 1989; 129: 687-702
- Estimating glomerular filtration rate from serum creatinine and cystatin C.N. Engl. J. Med. 2012; 367: 20-29
- Community surveillance of coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) Study: methods and initial two years' experience.J. Clin. Epidemiol. 1996; 49: 223-233
- Candidate gene association resource (care): design, methods, and proof of concept.Circ. Cardiovasc. Genet. 2010; 3: 267-275
- Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.PLoS One. 2008; 3: e3583
- A short questionnaire for the measurement of habitual physical activity in epidemiological studies.Am. J. Clin. Nutr. 1982; 36: 936-942
- Seasonal variation in 25-hydroxyvitamin D concentrations in the Cardiovascular Health Study.Am. J. Epidemiol. 2011; 174: 1363-1372
- Race and vitamin D binding protein gene polymorphisms modify the association of 25-hydroxyvitamin D and incident heart failure: the Atherosclerosis Risk in Communities Study (ARIC).JACC Heart Fail. 2015; (Published online April 08, 2015)https://doi.org/10.1016/j.jchf.2014.11.013
- Heart disease and stroke statistics–2014 update: a report from the American Heart Association.Circulation. 2014; 129: e28-292
- Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants.Eur. J. Epidemiol. 2013; 28: 205-221
- 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.J. Clin. Invest. 2002; 110: 229-238
- Vitamin D and diabetes.Endocrinol. Metab. Clin. North Am. 2014; 43: 205-232
- Race, vitamin D binding protein gene polymorphisms, 25-hydroxyvitamin D, and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study.Am. J. Clin. Nutr. 2015; (in press), (e-pub ahead of print)https://doi.org/10.3945/ajcn.115.107334
- Vitamin D supplementation improves cytopkine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.Am. J. Clin. Nutr. 2006; 83: 754-759
- 1,25(OH)2 vitamin D inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus.Circulation. 2009; 120: 687-698
- Vitamin D and cardiovascular disease: an appraisal of the evidence.Clin. Chem. 2014; 60: 600-609
- Vitamin D and African Americans.J. Nutr. 2006; 136: 1126-1129
- Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey.Osteoporos. Int. 2011; 22: 1745-1753
- A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness).Diabetologia. 2014; 57: 1159-1172