- •RCTs produced conflicting results on effects of early invasive strategy in NSTE-ACS.
- •Pooled data analysis showed reduction in recurrent ischemia and no mortality benefit.
- •There is high between-study heterogeneity in the reported rates of new MI.
- •Heterogeneity stems from ambiguous new MI definition and early intervention timing.
- •Impact of timing on new MI rates is stronger in studies with higher PCI rates.
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- Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.N. Engl. J. Med. 2001; 344: 1879-1887
- Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial. Randomized intervention trial of unstable angina.Lancet. 2002; 360: 743-751
- Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB trial. Thrombolysis in myocardial ischemia.Circulation. 1994; 89: 1545-1556
- Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy. Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH) Trial Investigators.N. Engl. J. Med. 1998; 338: 1785-1792
- Outcome at 1 year after an invasive compared with a non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomised trial. FRISC II Investigators. Fast Revascularisation during Instability in Coronary artery disease.Lancet. 2000; 356: 9-16
- Early invasive versus selectively invasive management for acute coronary syndromes.N. Engl. J. Med. 2005; 353: 1095-1104
- Benefit of early invasive therapy in acute coronary syndromes: a meta-analysis of contemporary randomized clinical trials.J. Am. Coll. Cardiol. 2006; 48: 1319-1325
- Long-term outcome of a routine versus selective invasive strategy in patients with non-ST-segment elevation acute coronary syndrome a meta-analysis of individual patient data.J. Am. Coll. Cardiol. 2010; 55: 2435-2445
- Early invasive versus conservative strategies for unstable angina & non-ST-elevation myocardial infarction in the stent era.Cochrane Database Syst. Rev. 2006; 3 (CD004815)
- Routine vs selective invasive strategies in patients with acute coronary syndromes: a collaborative meta-analysis of randomized trials.JAMA. 2005; 293: 2908-2917
- Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis.JAMA. 2008; 300: 71-80
- Early or late intervention in high-risk non-ST-elevation acute coronary syndromes: results of the ELISA-3 trial.EuroIntervention. 2013; 9: 54-61
- Early versus delayed invasive intervention in acute coronary syndromes.N. Engl. J. Med. 2009; 360: 2165-2175
- Immediate vs delayed intervention for acute coronary syndromes: a randomized clinical trial.JAMA. 2009; 302: 947-954
- Evaluation of prolonged antithrombotic pretreatment (“cooling-off” strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial.JAMA. 2003; 290: 1593-1599
- Immediate versus deferred coronary angioplasty in non-ST-segment elevation acute coronary syndromes.Heart. 2009; 95: 807-812
- Comparison of immediate vs early invasive strategy in patients with first acute non-ST-elevation myocardial infarction.Clin. Cardiol. 2010; 33: 650-655
- Influence of the timing of percutaneous coronary intervention on clinical outcomes in Non-ST-Elevation Myocardial Infarction.Korean Circ. J. 2013; 43: 725-730
- Optimal timing of invasive angiography in stable non-ST-elevation myocardial infarction: the Leipzig immediate versus early and late PercutaneouS coronary intervention triAl in NSTEMI (LIPSIA-NSTEMI Trial).Eur. Heart J. 2012; 33: 2035-2043
- A comparison of two invasive strategies in patients with non-ST elevation acute coronary syndromes: results of the Early or Late Intervention in unStable Angina (ELISA) pilot study. 2b/3a upstream therapy and acute coronary syndromes.Eur. Heart J. 2003; 24: 1401-1405
- Outcome of patients with non-ST segment elevation acute coronary syndrome undergoing early or delayed intervention.Zhonghua Xin Xue Guan Bing Za Zhi. 2010; 38: 865-869
- Optimal timing of coronary angiography and potential intervention in non-ST-elevation acute coronary syndromes.Eur. Heart J. 2011; 32: 32-40
- Early vs. delayed invasive strategy in patients with acute coronary syndromes without ST-segment elevation: a meta-analysis of randomized studies.QJM. 2011; 104: 193-200
- Optimal timing of coronary invasive strategy in non-ST-segment elevation acute coronary syndromes: a systematic review and meta-analysis.Ann. Intern. Med. 2013; 158: 261-270
- Early versus delayed percutaneous coronary intervention for patients with non-ST segment elevation acute coronary syndrome: a meta-analysis of randomized controlled clinical trials.Catheter. Cardiovasc. Interv. 2013; 81: 223-231
Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. In: JPT H, S G, editors.: The Cochrane Collaboration, 2011. Available from: http://www.cochrane-handbook.org., 2011.
- The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.BMJ. 2009; 339: b2700
- Timing of intervention and outcome in non-ST-elevation acute coronary syndromes: there is risk on both sides of the curve.Int. J. Cardiol. 2014; 177: 23-24
- Consideration of a new definition of clinically relevant myocardial infarction after coronary revascularization: an expert consensus document from the Society for Cardiovascular Angiography and Interventions (SCAI).J. Am. Coll. Cardiol. 2013; 62: 1563-1570
- Avatar of the universal definition of periprocedural myocardial infarction.J. Am. Coll. Cardiol. 2013; 62: 1571-1574