Whitening of skin is main goal of cosmetics and beauty industry. However, mechanism
of melanin synthesis is not clearly known in vertebrate model, especially in lipid
metabolism. We maintained zebrafish in low-temperature group(18?), LT group for 76
weeks to compare melanogenesis and lipid metabolism with normal-temperature group(28?),
NT group. LT group showed 51% lower melanin content than NT group with 48% and 18%
less body weight and height. Serum total cholesterol was significantly reduced in
LT group up 85.8 mg/dL compared with NT group 162.8 mg/dL. Serum triglyceride level
was also decreased in LT group by 14% and AST and ALT level was also decreased in
LT group. Hepatic inflammatory profile was enhanced in LT group, indicating that inflammation
was reduced by the low-temperature incubation. In adipose tissue, LT group showed
54% smaller size than NT group. In conclusion, low-temperature maintenance of zebrafish
caused less production of melanin and lowering of serum cholesterol with reduction
of adipose tissue, These results may apply to development of skin whitening method
and lipid-lowering strategy.
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Publication history
EAS-0190
Identification
Copyright
© 2015 Published by Elsevier Inc.
