Abstract| Volume 241, ISSUE 1, e197, July 2015

Inhibition of melanin synthesis in zebrafish by low-temperature maintenance and lowering of serum cholesterol

      Whitening of skin is main goal of cosmetics and beauty industry. However, mechanism of melanin synthesis is not clearly known in vertebrate model, especially in lipid metabolism. We maintained zebrafish in low-temperature group(18?), LT group for 76 weeks to compare melanogenesis and lipid metabolism with normal-temperature group(28?), NT group. LT group showed 51% lower melanin content than NT group with 48% and 18% less body weight and height. Serum total cholesterol was significantly reduced in LT group up 85.8 mg/dL compared with NT group 162.8 mg/dL. Serum triglyceride level was also decreased in LT group by 14% and AST and ALT level was also decreased in LT group. Hepatic inflammatory profile was enhanced in LT group, indicating that inflammation was reduced by the low-temperature incubation. In adipose tissue, LT group showed 54% smaller size than NT group. In conclusion, low-temperature maintenance of zebrafish caused less production of melanin and lowering of serum cholesterol with reduction of adipose tissue, These results may apply to development of skin whitening method and lipid-lowering strategy.
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