Obesity is the major problem of modern society, which is associated with such metabolic disorders as insulin resistance (IR) and type II diabetes. Thus, it is of a current interest to develop novel treatment modalities that could improve the lipid imbalance and restore insulin sensitivity. Recent studies indicate that bioactive lipid N-stearoylethanolamine is able to correct lipid imbalance, showing membrane-stabilizing and cytoprotective properties. According to this, we explore the effect of NSE on indicators of IR development at a rat model of HFD overload.
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© 2015 Published by Elsevier Inc.