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Association of measles and mumps with cardiovascular disease: The Japan Collaborative Cohort (JACC) study

      Highlights

      • This is the first study to prospectively investigate the positive impact of infections on cardiovascular disease.
      • Measles and mumps infections were associated with decreased risks of mortality from cardiovascular disease.
      • A higher number of infections was associated with a lower risk of mortality from cardiovascular disease.

      Abstract

      Objective

      Although it has been suggested that exposure to infections during childhood could decrease risk of atherosclerotic cardiovascular disease (CVD), the evidence is scarce. We investigated the association of measles and mumps with CVD.

      Methods

      43,689 men and 60,147 women aged 40–79 years at baseline (1988–1990) completed a lifestyle questionnaire, including their history of measles and mumps, and were followed until 2009. Histories of infections were categorized as having no infection (reference), measles only, mumps only, or both infections. Hazard ratios (HR) for mortality from CVD across histories of infections were calculated.

      Results

      Men with measles only had multivariable HR (95% confidence interval) of 0.92 (0.85–0.99) for total CVD, those with mumps only had 0.52 (0.28–0.94) for total stroke and 0.21 (0.05–0.86) for hemorrhagic stroke, and those with both infections had 0.80 (0.71–0.90) for total CVD, 0.71 (0.53–0.93) for myocardial infarction, and 0.83 (0.69–0.98) for total stroke. Women with both infections had 0.83 (0.74–0.92) for total CVD and 0.84 (0.71–0.99) for total stroke. We also compared subjects with measles only or mumps only (reference) and those with both infections. Men with both infections had 0.88 (0.78–0.99) for total CVD. Women with both infections had 0.85 (0.76–0.94) for total CVD, 0.79 (0.67–0.93) for total stroke, 0.78 (0.62–0.98) for ischemic stroke and 0.78 (0.62–0.98) for hemorrhagic stroke.

      Conclusions

      Measles and mumps, especially in case of both infections, were associated with lower risks of mortality from atherosclerotic CVD.

      Keywords

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      References

        • Pesonen E.
        • Andsberg E.
        • Ohlin H.
        • Puolakkainen M.
        • Rautelin H.
        • Sarna S.
        • et al.
        Dual role of infections as risk factors for coronary heart disease.
        Atherosclerosis. 2007; 192: 370-375
        • Roivainen M.
        • Alfthan G.
        • Jousilahti P.
        • Kimpimäki M.
        • Hovi T.
        • Tuomilehto J.
        Enterovirus infections as a possible risk factor for myocardial infarction.
        Circulation. 1998; 98: 2534-2537
        • Siscovick D.S.
        • Schwartz S.M.
        • Corey L.
        • Grayston J.T.
        • Ashley R.
        • Wang S.P.
        • et al.
        Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults: the cardiovascular health Study.
        Circulation. 2000; 102: 2335-2340
        • Roivainen M.
        • Viik-Kajander M.
        • Palosuo T.
        • Toivanen P.
        • Leinonen M.
        • et al.
        Infections, inflammation, and the risk of coronary heart disease.
        Circulation. 2000; 101: 252-257
        • Mayr M.
        • Kiechl S.
        • Willeit J.
        • Wick G.
        • Xu Q.
        Infections, immunity, and atherosclerosis: associations of antibodies to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis.
        Circulation. 2000; 102: 833-839
        • Zhu J.
        • Nieto F.J.
        • Horne B.D.
        • Anderson J.L.
        • Muhlestein J.B.
        • Epstein S.E.
        Prospective study of pathogen burden and risk of myocardial infarction or death.
        Circulation. 2001; 103: 45-51
        • Rook G.A.
        99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis.
        Clin. Exp. Immunol. 2010; 160: 70-79
        • Ait-Oufella H.
        • Horvat B.
        • Kerdiles Y.
        • Herbin O.
        • Gourdy P.
        • Khallou-Laschet J.
        • et al.
        Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice.
        Circulation. 2007; 116: 1707-1713
        • Anderson R.M.
        • May R.M.
        Age-related changes in the rate of disease transmission: implications for the design of vaccination programmes.
        J. Hyg. (Lond). 1985; 94: 365-436
        • Tamakoshi A.
        • Ozasa K.
        • Fujino Y.
        • Suzuki K.
        • Sakata K.
        • Mori M.
        • et al.
        Cohort profile of the Japan collaborative cohort study at final follow-up.
        J. Epidemiol. 2013; 23: 227-232
        • Isomura S.
        Measles and measles vaccine in Japan.
        Nagoya J. Med. Sci. 1993; 55: 23-32
        • Bach J.F.
        The effect of infections on susceptibility to autoimmune and allergic diseases.
        N. Engl. J. Med. 2002; 347: 911-920
        • Nafstad Per B.B.
        • Skrondal A.
        • Nystad W.
        Early respiratory infections, asthma, and allergy: 10-year follow-up of the Oslo birth cohort.
        Pediatrics. 2005; 116: 255-262
        • Sasaki N.
        • Yamashita T.
        • Takeda M.
        • Shinohara M.
        • Nakajima K.
        • Tawa H.
        • et al.
        Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice.
        Circulation. 2009; 120: 1996-2005
        • Kita Y.
        • Okayama A.
        • Ueshima H.
        • Wada M.
        • Nozaki A.
        • Choudhury S.R.
        • et al.
        Stroke incidence and case fatality in Shiga, Japan 1989-1993.
        Int. J. Epidemiol. 1999; 28: 1059-1065
        • Baba S.
        • Ozawa H.
        • Sakai Y.
        • Terao A.
        • Konishi M.
        • Tatara K.
        Heart disease deaths in a Japanese urban area evaluated by clinical and police records.
        Circulation. 1994; 89: 109-115