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Coronary calcium assessment with computed tomography in HIV-infected patients

      The meta-analysis of D'Ascenzo et al. [
      • D'Ascenzo F.
      • Cerrato E.
      • Calcagno A.
      • Grossomarra W.
      • Ballocca F.
      • Omedè P.
      • Montefusco A.
      • Veglia S.
      • Barbero U.
      • Gili S.
      • Cannillo M.
      • Pianelli M.
      • Mistretta E.
      • Raviola A.
      • Salera D.
      • Garabello D.
      • Mancone M.
      • Estrada V.
      • Escaned J.
      • De Marie D.
      • Abbate A.
      • Bonora S.
      • Zoccai G.B.
      • Moretti C.
      • Gaita F.
      High prevalence at computed coronary tomography of non-calcified plaques in asymptomatic HIV patients treated with HAART: a meta-analysis.
      ] included 9 studies comparing patients with human immunodeficiency virus (HIV) without symptoms of coronary artery disease (CAD) to HIV-negative controls. Most HIV-positive patients (mean age 47 years) were on antiretroviral therapy. Results showed that prevalence of coronary artery calcium (CAC) or calcified coronary plaques, as assessed with cardiac computed tomography (CT), did not differ between HIV-positive and HIV-negative patients. However, the prevalence of non-calcified plaques in HIV-positive patients was 3-fold higher compared with HIV-negative patients with similar Framingham cardiovascular risk scores (FRS) (58% vs. 17%) .
      Figure thumbnail gr1
      Fig. 1Box plots of coronary artery calcium (CAC) age/sex percentile ranks of controls (mean 43.48 ± 37.4; median 55.0) and HIV-positive patients (mean 38.6 ± 34.3; median 35.0), matched for age, gender and Framingham 10-year risk score (p = 0.59).

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