Objectives: In chronic kidney disease (CKD), the decline of estimated glomerular filtration rate (eGFR) associates with increased cardiovascular mortality, which is not fully explained by the dyslipidemia developed by these subjects. Our aim was to study the association of eGFR decline with changes in lipoprotein composition, size and selected functionalities: for HDL, the in vitro cholesterol efflux capacity (CEC) and its antioxidant effects, a potential athero-protective mechanism, and, for LDL, the binding to arterial proteoglycans, an atherogenic mechanism.
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EAS16-0812 Workshop 2.1: Lipoproteins and Extracellular Matrix
© 2016 Published by Elsevier Inc.