Abstract| Volume 252, e237, September 2016

Increased lipoprotein binding to arterial proteoglycans and normal macrophage cholesterol efflux capacity define the pro-atherogenic feature of CKD dyslipidemia

      Objectives: In chronic kidney disease (CKD), the decline of estimated glomerular filtration rate (eGFR) associates with increased cardiovascular mortality, which is not fully explained by the dyslipidemia developed by these subjects. Our aim was to study the association of eGFR decline with changes in lipoprotein composition, size and selected functionalities: for HDL, the in vitro cholesterol efflux capacity (CEC) and its antioxidant effects, a potential athero-protective mechanism, and, for LDL, the binding to arterial proteoglycans, an atherogenic mechanism.
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