The role of inflammation in the association between adiposity and subclinical atherosclerosis

      Objectives: Obesity is a well-established risk factor for cardiovascular disease (CVD). Approximately 45% of this risk is mediated via the traditional risk factors blood pressure, glucose and cholesterol. The mechanisms underlying the remaining part of this risk are unclear. Inflammation is a candidate because adipocytes excrete cytokines that may induce a low-grade inflammatory state. We investigated to what extent inflammation mediates the associations of overall and visceral adiposity with atherosclerosis.
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