Abstract| Volume 252, e106, September 2016

Inflammation potently suppresses abca1-mediated cholesterol efflux from macrophages, and not adipocytes, via activation of JAK/STAT pathway

      Objectives: Recruitment of pro-inflammatory M1 macrophages into adipose-tissue during obesity results in localised inflammation. Adipocytes are a major store of cholesterol in the body while macrophage efflux is critical to protect against atherosclerosis. This study investigated the effects of inflammation on cholesterol efflux from macrophages and adipocytes to understand the implications of obesity-associated inflammation on cellular cholesterol trafficking.
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