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Associations among oxidative stress, Lp-PLA2 activity and arterial stiffness according to blood pressure status at a 3.5-year follow-up in subjects with prehypertension

  • Minkyung Kim
    Affiliations
    Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, South Korea
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  • Hye Jin Yoo
    Affiliations
    National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea

    Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, South Korea
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  • Minjoo Kim
    Affiliations
    Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, South Korea
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  • Hyeon Yeong Ahn
    Affiliations
    Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, South Korea
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  • Jiyeong Park
    Affiliations
    National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea

    Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, South Korea
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  • Sang-Hyun Lee
    Affiliations
    Department of Family Practice, National Health Insurance Corporation, Ilsan Hospital, Goyang, South Korea
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  • Jong Ho Lee
    Correspondence
    Corresponding author. Department of Food & Nutrition, College of Human Ecology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
    Affiliations
    Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, South Korea

    National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, South Korea

    Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, South Korea
    Search for articles by this author

      Highlights

      • Persistent prehypertensive group showed increases in Lp-PLA2, ox-LDL, and ba-PWV at 3.5 years.
      • Persistent prehypertensive group showed greater increases in ox-LDL and Lp-PLA2 than normotensive group.
      • Systolic blood pressure was positively correlated with Lp-PLA2, ox-LDL, 8-epi-PGF, and ba-PWV.
      • Increased ox-LDL hydrolysis by Lp-PLA2 may enhance arterial stiffness in persistent prehypertension without increase in BP.

      Abstract

      Background and aims

      We aimed to determine changes in oxidative stress, lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and arterial stiffness in subjects with persistent prehypertensive symptoms during a 3.5-year follow-up period.

      Methods

      We divided 254 subjects with prehypertension according to their blood pressure (BP) status at 3.5 years of follow-up into three groups: reversed normotensive, persistent prehypertensive and developed hypertensive group. BP, serum lipid profile, oxidized LDL (ox-LDL), Lp-PLA2 activity and brachial-ankle pulse wave velocity (ba-PWV) were measured at baseline and the 3.5-year follow-up.

      Results

      The reversed normotensive group showed a significant reduction in average BP (14.7/10.1 mmHg), whereas the developed hypertensive group showed a significant increase in average BP (15.2/11.5 mmHg). The persistent prehypertensive group showed increases in serum lipid profiles, circulating levels of Lp-PLA2 activity, ox-LDL and arterial stiffness as measured by ba-PWV at 3.5 years. The persistent prehypertensive and developed hypertensive groups showed greater increases in ox-LDL than the reversed normotensive group. The developed hypertensive group showed greater increases in Lp-PLA2, 8-epi-PGF, and ba-PWV than those observed in the reversed normotensive and persistent prehypertensive groups. In all subjects, changes (Δ) in systolic blood pressure (SBP) positively correlated with Δ Lp-PLA2, Δ ox-LDL, Δ urinary 8-epi-PGF and Δ ba-PWV.

      Conclusions

      This study indicates that in persistent prehypertension, increased ox-LDL hydrolysis by Lp-PLA2 enhances arterial stiffness without an age-related increase in BP.

      Keywords

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