Highlights
- •Certain miRNAs present in aortic tissue are associated with a diagnosis of abdominal aortic aneurysm.
- •Certain miRNAs present in circulating blood are associated with a diagnosis of abdominal aortic aneurysm.
- •Certain circulating miRNAs may be useful as biomarkers indicating the presence of abdominal aortic aneurysm.
Abstract
Background and aims
There is increasing interest in identifying novel methods for abdominal aortic aneurysm
(AAA) diagnosis. Non-coding RNA molecules such as microRNAs (miRNAs) are stable within
the circulation and may serve as biomarkers for AAA. This systematic review aimed
to identify miRNAs associated with a diagnosis of human AAA based on currently published
original research.
Methods
A systematic search of the MEDLINE and EMBASE databases identified studies assessing
miRNA expression in abdominal aortic tissue or circulating blood from human AAA cases
compared to non-aneurysmal controls. Data from included studies were extracted to
assess methods and results after independent quality assessment by two reviewers.
Results
15 studies were included in this review. 11 studies obtained aortic tissue samples
from 195 AAA cases and 104 controls with normal aortas. Nine studies obtained circulating
blood samples from 526 AAA cases and 441 controls. miR-21 was differentially expressed
in AAA tissue in five separate studies, with four studies reporting upregulation and
one reporting downregulation. Seven other miRNAs were differentially expressed in
AAA tissue in two separate studies. 15 circulating miRNAs were differentially expressed
in two or more separate studies. miR-155 and miR-29b were the only miRNAs differentially
expressed in two separate tissue- and blood-based studies. 11 studies offered mechanistic
explanations of the role of miRNAs in AAA pathology through exploration of gene targets.
Three studies assessed the diagnostic potential of circulating miRNAs with receiver
operating characteristic curves. Only one study assessed the prognostic potential
of circulating miRNAs in predicting AAA growth.
Conclusions
Several miRNAs have been found to be associated with human AAA. Their utility as AAA
biomarkers requires further investigation.
Keywords
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Article info
Publication history
Published online: March 08, 2017
Accepted:
March 6,
2017
Received in revised form:
March 2,
2017
Received:
November 18,
2016
Identification
Copyright
© 2017 Published by Elsevier Ireland Ltd.
