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Abstract only| Volume 263, e107-e108, August 01, 2017

Elevated systemic heme and iron levels as risk factor for vascular dysfunction and atherosclerosis: Evidence from a beta-thalassemia cohort study

DOI:https://doi.org/10.1016/j.atherosclerosis.2017.06.344
Elevated systemic heme and iron levels as risk factor for vascular dysfunction and atherosclerosis: Evidence from a beta-thalassemia cohort study
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      Aim: Increasing evidence from animal studies suggests that free heme exerts vasculotoxic, pro-inflammatory and pro-coagulant effects due to its ability to trigger endothelial and immune cells activation. Moreover, a role for heme and iron has been recently postulated in the pathogenesis of atherosclerosis. Whether these findings are clinically relevant has to be determined.
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      DOI: https://doi.org/10.1016/j.atherosclerosis.2017.06.344

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      © 2017 Published by Elsevier Inc.

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