Aim: The phenotypic modulation of vascular smooth muscle cells (VSMCs) is a key cellular
event driving vascular remodeling. Recent studies have identified HMGB1 as a principal
effector to mediate biological functions in VSMCs, however, the molecular mechanisms
by which elicits VSMC responses are poorly defined. Thus, we investigated the role
of HMGB1 on the production of inflammatory cytokines in VSMCs as well as the underlying
molecular mechanisms.
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© 2017 Published by Elsevier Inc.
