Impact of physical activity and sedentary behavior on biological risk factors of carotid atherosclerotic plaque instability

      Aim: Carotid atherosclerosis plaque instability is increased by intraplaque hemorrhage (IPH) and neovascularization. Oxidative stress is known to promote these two risk factors and induce a vicious circle with IPH and neovascularization. Moreover, it was shown that regular physical activity can reduce oxidative stress by increasing antioxidant defenses whereas sedentary behavior can increase oxidative stress independently to physical activity. The aim of this study was therefore to evaluate the effects of both physical activity and sedentary behavior on the carotid plaque histological characteristics and oxidative stress in patients at high-risk of stroke.
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