Abstract| Volume 263, e222-e223, August 2017

Lipidomic study of the impact of eicosapentaenoic acid (EPA) on abca1-mediated cholesterol efflux from human macrophages

      Aim: A diet rich in n-3 polyunsaturated fatty acids (PUFAs) is cardioprotective. PUFAs incorporation into membrane phospholipids (PLs) modifies the composition, which may influence membrane protein functions. We reported in human macrophages that the incorporation of eicosapentaenoic acid (EPA) (C20:5, 70 μM) reduced the anti-atherogenic ABCA1 pathway. We conducted a more complete analysis of the PLs modifications.
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