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Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with diabetic neuropathy

      Aim: Diabetic neuropathy (DN) develops on a background of hyperglycemia and is associated with increased oxidative stress and altered nitric oxide (NO) production. Previous studies have shown that the enhanced oxidative stress in diabetes correlates with decreased paraoxonase-1 (PON1) enzyme activity. Elevated ADMA levels are linked to oxidative stress reducing the synthesis of NO and inducing superoxide production by uncoupling NO synthase. Oxidative stress induces changes in nerve conduction velocity in diabetic patients. There is strong evidence that alpha-lipoic acid (ALA) as an antioxidant may improve nerve conduction and relieve neuropathic pain. We aimed to determine the PON1 paraoxonase and arylesterase activities, ADMA and NO levels in DN and to clarify the relationship between these parameters and nerve conduction velocity after treatment with ALA.
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