Aim: Diabetic neuropathy (DN) develops on a background of hyperglycemia and is associated
with increased oxidative stress and altered nitric oxide (NO) production. Previous
studies have shown that the enhanced oxidative stress in diabetes correlates with
decreased paraoxonase-1 (PON1) enzyme activity. Elevated ADMA levels are linked to
oxidative stress reducing the synthesis of NO and inducing superoxide production by
uncoupling NO synthase. Oxidative stress induces changes in nerve conduction velocity
in diabetic patients. There is strong evidence that alpha-lipoic acid (ALA) as an
antioxidant may improve nerve conduction and relieve neuropathic pain. We aimed to
determine the PON1 paraoxonase and arylesterase activities, ADMA and NO levels in
DN and to clarify the relationship between these parameters and nerve conduction velocity
after treatment with ALA.
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© 2017 Published by Elsevier Inc.
